Steroid 18-oxidation

Last modified: Tue Jul 6 11:16:55 BST 2004

18-Hydroxysteroid
NADPH
18-Oxosteroid

Steroid carbon nomenclature

Pathways:

Reaction: steroid oxidation at C18
Enzyme: P450c18 (steroid 18-hydroxylase), CYP11B
EC 1.14.15.5

References

  1. Ruckpaul, K. and Rein, H., Eds. (1990) Frontiers in Biotransformation, vol. 3: Molecular Mechanisms of Adrenal Steroidogenesis and Aspects of Regulation and Application. Taylor & Francis, London.
  2. Domalik, L.J., Chaplin, D.D., Kirkman, M.S., Wu, R.C., Liu, W.W., Howard, T.A., Seldin, M.F. and Parker, K.L. (1991) Different isozymes of mouse 11ß-hydroxylase produce mineralocorticoids and glucocorticoids. Mol. Endocrinol. 5, 1853-1861.
  3. Nomura, M., Morohashi, K., Kirita, S., Nonaka, Y., Okamoto, M., Nawata, H. and Omura, T. (1993) Three forms of rat CYP11B genes: 11ß-hydroxylase gene, aldosterone synthase gene, and a novel gene. J. Biochem. (Tokyo) 113, 144-152.
  4. Mellon, S.H., Bair, S.R. and Monis, H. (1995) P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities. J. Biol. Chem. 270, 1643-1649.
  5. Nonaka, Y., Takemori, H., Halder, S.K., Sun, T., Ohta, M., Hatano, O., Takakusu, A. and Okamoto, M. (1995) Frog cytochrome P-450 (11ß, aldo), a single enzyme involved in the final steps of glucocorticoid and mineralocorticoid biosynthesis. Eur. J. Biochem. 229, 249-256.
  6. Okamoto, M., Nonaka, Y., Ohta, M., Takemori, H., Halder, S.K., Wang, Z.N., Sun, T., Hatano, O., Takakusu, A. and Murakami, T. (1995) Cytochrome P450(11ß): structure-function relationship of the enzyme and its involvement in blood pressure regulation. J. Steroid. Biochem. Mol. Biol. 53, 89-94.

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