last modified:
last modified:
-component
The eukaryotic microsomal P450 system contains two components:
NADPH:P450 reductase (CPR), a flavoprotein containing both FAD and FMN,
and P450. CPR appears to be a fusion protein consisting of domains which are
homologous to flavodoxin
(FMN domain) and
ferredoxin:NADP+ reductase (FAD domain).
A soluble monooxygenase P450BM-3 from Bacillus megaterium
exists as a single polypeptide chain with two functional parts, the haem (P450)
and flavin (CPR) domains, and represents a unique bacterial
one-component P450 system. Mammalian nitric oxide synthase (NOS)
contains FAD, FMN and haem and was the first eukaryotic
self-sufficient P450-like system described. The C-terminal domain
of NOS is clearly homologous to CPR, whereas its N-terminal (oxygenase)
domain has a unique fold different from that of P450s.
-Component of bacterial
NADPH:sulphite reductase contains FAD and FMN and is similar to CPR.
Gene Species PIR SwissProt GenBank/EMBL/DDBJ PRF
CPR rat A36073 P00388 M10068 M12516 J00718 S70373 1701250A
1103351A
1203241A
rab A25505 P00389 D00101 X04610 1211284A
mou P37040 D17571 2017207A
ham Q60451 D83230
hum A60557 P16435 T08991 T15414 1515351A
1516146A
1808183A
Q16455 S90469
gpi S27158 P37039 D10498 1904143A
pig A25584 P04175 L33893 1302145A
1107181A
1207184A
1103184A
tro A28577 P19618 1309284A
Dme Q27597 X93090
Dmt P91655 U65749
Mdo Q07994 L19897 S62221 S62726 S62730 2005235A
Cel Q09590 U21322
Z35595
Sce A41447 P16603 D00316 D13788 1408205A
Ctr A37890 P37201 M35199 1616317A
Cma S49140 P50126 X76226 D25327
Spo S29123 P36587 X64702 S46250 1819195A
Q09744 Z54140
Ani S38427 Q00141 Z26938 2119198A
Ath S21530 X66016
Ath S21531 X66017
Cro S31502 Q05001 X69791 Y09417
Htu S37157 Q96561 Z26250
Htu S37156 Q96560 Z26251
Htu Q42830 U58629
Pau A47298 P37116 L07843 1911469A
Psm Q40916 Z49767
Vsa S37159 Q43235 Z26252
pea O04434 AF002698
Gene Species PIR SwissProt GenBank/EMBL/DDBJ PRF
CYP102 Bme A34286 P14779 J04832 1510269A CYP102 Bsu O08336 U93874 Cyp2b-10 mou X99715 + CPR
eNOS bov A42841 A46033 P29473 M99057 L27056 M95674 M89952 1815263A
1817310A
1905357A
hum S24052 A42867 P29474 L10693 L10694 L10695 L10696 1816206A
L10697 L10698 L10699 L10700 1817302A
L10701 L10702 L10703 L10704 1920328A
L10705 L10706 L10707 L10708
L10709
X76303 X76304 X76305 X76306
X76307 X76308 X76309 X76310
X76311 X76312 X76313 X76314
X76315 X76316
M95296 L23210 M93718 L26914
D26607
gpi U76736
mou U53142
pig U59924
rat Q62600 U02534
she U76738
nNOS hum S28878 P29475 L02881 D16408 U31466
U17299 U17300 U17301 U17302
U17303 U17304 U17305 U17306
U17307 U17308 U17309 U17310
U17311 U17312 U17313 U17314
U17315 U17316 U17317 U17318
U17319 U17320 U17321 U17322
U17323 U17324 U17325 U17326
U66360 U66361 U66362
gpi U76737
mou JN0609 D14552
rat S16233 P29476 X59949 U67309 1712320A
she X99042
Dme U25117
Rhp U59389
iNOS hum A47475 S47566 P35228 U05810 X73029 L09210 L26055 2001203A
D29675 L24553 T15817 D26525
U31511 X81701 X81702 Z49251
X85759 X85760 X85761 X85762
X85763 X85764 X85765 X85766
X85767 X85768 X85769 X85770
X85771 X85772 X85773 X85774
X85775 X85776 X85777 X85778
X85779 X85780 X85781
mou A43271 A46186 P29477 M87039 L09126 L23806 M84373 1807286A
JN0458 M92649 U43428 1808352A
rat JC1472 JN0457 Q06518 D14051 X76881 L12562 U26686 1909128A
S40126 S47647 D12520 U03699 L36063 S71597
S38253 X95629 Z69839 D44591 U48829
D83661
pig U59390
bov Q27995 U18331
got U29085
chi Q90703 U34045 U46504 D85422
gol X97603
tro X97013
iNOSP hum U65689 U65690 U65691 U65692
U65693 U65694 U65695 U65696
U65697 U65698 U65699
-component
(EC 1.8.1.2)Gene Species PIR SwissProt GenBank/EMBL/DDBJ PRF cysJ Sty A34231 P38039 M23007 J05009 1515279A cysJ Eco B34231 P38038 M23008 J05057 cysJ Trp S34190 Z23169 met10 Sce S45174 JC2514 P39692 L26503 D44610 U05820 2020353A met10 Scb L26504 2020353B
To the flavodoxins page ( ).
To the ferredoxin:NADP+ reductase superfamily page ( ).
To the Todd Porter's CPR page
Ani = Aspergillus niger Ath = Arabidopsis thaliana Bme = Bacillus megaterium bov = bovine Cal = Candida albicans Cel = Caenorhabditis elegans (nematode worm) chi = chicken Cma = Candida maltosa Ctr = Candida tropicalis Dme = Drosophila melanogaster (fruit fly) Dmt = Drosophila mettleri Eco = Escherichia coli Fox = Fusarium oxysporum gol = goldfish (Carassius auratus) got = goat gpi = guinea pig ham = hamster Htu = Helianthus tuberosus (Jerusalem artichoke) hum = human Mdo = Musca domestica (house fly) mou = mouse Pau = Phaseolus aureus (syn. Vigna radiata, mung bean) pig = pig Psm = Pseudotsuga menziesii rab = rabbit rat = rat Rhp = Rhodnius prolixus Scb = Saccharomyces carlsbergensis Sce = Saccharomyces cerevisiae (baker's yeast) she = sheep Spo = Schizosaccharomyces pombe Sty = Salmonella typhimurium tro = trout Trp = Thiocapsa roseopersicina Vsa = Vicia sativa
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