Research Groups

Pavan Jutur

Omics of Algae

Group Leader

Research Interests and Description

Pavan Jutur

International Centre for Genetic Engineering and Biotechnology
Aruna Asaf Ali Marg
110 067 New Delhi, India

E-mail: jppavanicgeb.res.in, jppavangmail.com
Office tel: +91-11-26741358 ext 451
Office fax: +91-11-26742316

Education

Pondicherry University, Pondicherry, India, PhD, 2005
Pondicherry University, Pondicherry, India, MPhil, 2001
Kuvempu University, Davanagere, Karnataka, India, MSc, 1999

Career History

Since 2017, Group Leader, Omics of Algae Group, Integrative Biology, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2012-2017, Team Leader, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2009-2012, Postdoctoral Research Associate, University of Nebraska, Lincoln, USA
2008-2009, Lecturer, BITS-Pilani (Goa Campus), Goa, India
2006-2008, ISSAR Pharma Pvt Ltd/USP India Pvt Ltd, Hyderabad, India
2005-2006, Research Associate, University of Hyderabad, Hyderabad, India

Teaching Activity

Since 2015, Teaching ‘Cell Biology & Molecular Biology of Cells’ and ‘Synthetic and Systems Biology’ Course to pre-doctoral students.

Scientific Activity

Our objective is to understand basic biology and metabolic/regulatory pathways in unicellular photosynthetic model microalga Chlamydomonas reinhardtii regarded as non-oleaginous. While under optimal growth conditions, it synthesizes fatty acids principally for esterification into membrane lipids, under conditions limiting to growth, particularly nutrient deprivation, it slows down the cell proliferation and alters the lipid biosynthetic pathways towards the formation and accumulation of the carbohydrates (starch) and neutral lipid triacylglycerols (TAGs). TAGs are one of the most energy-rich forms of reduced carbon available from nature. They can be converted to biodiesel by trans-esterification with methanol in the presence of an acid or alkali catalyst. C. reinhardtii is unlikely to be chosen for biofuel production. However, it is a model alga whose complete genome is available and used as a reference to understand metabolic and regulatory networks involved in lipid metabolism and TAG accumulation. For economic viability and sustainability of algal biofuels, it is essential to understand the basic biology of potential microalgae, particularly the effects of environmental stresses on cellular metabolisms and the regulation of biosynthetic pathways of fatty acids and TAGs, as well as carbon fixation and allocation. Neutral lipid biosynthesis and turnover have been studied in higher eukaryotes particularly yeast, mice, and the model plant Arabidopsis thaliana where extensive knowledge exists on lipid metabolism and several key enzymes identified. However, these pathways are not fully documented in microalgae and little is known about the enzymes involved in the formation, accumulation, or degradation of TAGs. More research is needed to understand signal perception and transduction under stress and different molecular mechanisms leading to TAG and starch accumulations in microalgae. In this context, rapidly developing systems-level omics analyses (genomics, transcriptomics, proteomics, metabolomics), which are both sensitive and quantitative, and the availability of annotated genomes allow us to investigate changes in response to environmental stress. This may provide useful hypotheses for microalgal strain improvement to optimize their biofuel production.

Currently, our research project focuses on:

  • Identification and characterization of robust microalgae from various collections for the genetic improvements for biofuel production.
  • Genome sequencing and annotation of selected microalgae for facilitating pathway engineering.
  • Investigating components of lipid biosynthetic pathway and its regulation in microalgae.
  • Characterization of quality of lipid in the microalgae and corresponding biosynthetic pathways. 
  • Engineering microalgae for improving the quality of lipid for biodiesel production.
  • Study of genetic mechanism and enzymes responsible for self-flocculation and its exploitation in algae.

Our findings will provide important breakthrough on central metabolism in these microalgae, which are required for biotechnological improvement of next-generation biofuel production.

Selected publications

Kapase, V.U., Nesamma, A.A., Jutur, P.P. 2018. Identification and characterization of candidates involved in production of OMEGAs in Microalgae: a gene mining and phylogenomics approach. Prep Biochem Biotechnol doi: 10.1080/10826068.2018. 1476886 PubMed link

Ashwani, K.R., Asha, A.N., and P.P. Jutur. Stress Biology in Microalgae Depicts Molecular Insights for Simultaneous Production of Lipids and High Value Precursors. Adv Biotech & Micro. 6(5): 555699, 2017. doi: 10.19080/AIBM.2017.06.555699.

Kashif, M.S., Asha, A.N., Abdin, M.Z., and P.P. Jutur. Evaluation of growth and lipid profiles in six different microalgal strains for biofuel production. In Recent Advances in Bioenergy Research, Proceedings of the Second International Conference. edited by Kumar S, et al. Springer Singapore; pp. 3-16, 2017. doi: 10.1007/978-981-10-6107-3_1.

Sardar, R., Kashif, M.S., and P.P. Jutur. Identification of transcription hubs that control lipid metabolism and carbon concentrating mechanism in model microalgae Chlamydomonas reinhardtii using regulatory networks. International Conference on Bioinformatics and Systems Biology (BSB), Allahabad, pp. 1-4, 2016. doi: 10.1109/BSB.2016.7552116.

Jutur. P.P., Asha, A.N., and M.S. Kashif. Algae-derived marine oligosaccharides and their biological applications. Frontiers in Marine Science 3(83): 1-5, 2016. doi: 10.3389/fmars. 2016.00083.

Asha, A.N., Kashif, M.S., and P.P. Jutur. De novo transcriptomics in marine microalgae: an advanced genetic engineering approach for next-generation renewable biofuels. In Marine OMICS: Principles and Applications. edited by S.K. Kim: CRC Press, pp. 283-296, August 2016. doi: 10.1201/9781315372303-16.

Singh, R., Mattam, A.J., Jutur, P.P., and S.S. Yazdani. Synthetic Biology in Biofuels Production. In Reviews in Cell Biology and Molecular Medicine. 2: 144-176, 2016. doi: 10.1002/3527600906.mcb.201600003.

Jutur, P.P., and A.N. Asha. Marine Microalgae: Exploring the Systems through an Omics Approach for Biofuel Production. In Marine Bioenergy: Trends and Developments. edited by S.K. Kim and C.G. Lee: CRC Press, pp. 149-162, 2015. doi: 10.1201/b18494-12.

Jutur, P.P., and A.N. Asha. Genetic Engineering of Marine Microalgae to Optimize Bioenergy Production. In Handbook of Marine Microalgae: Biotechnology Advances. edited by S.K. Kim: Elsevier Science, pp. 405-414, 2015. doi: 10.1016/B978-0-12-800776-1.00024-8.

Asha, A.N., Kashif, M.S., and P.P. Jutur. Genetic Engineering of Microalgae for Production of Value-Added Ingredients. In Handbook of Marine Microalgae: Biotechnology Advances. edited by S.K. Kim: Elsevier Science, pp. 371-381, 2015. doi: 10.1016/B978-0-12-800776-1.00026-1.

Jutur, P.P., and A.R. Reddy. Isolation, purification and properties of new restriction endonucleases from Bacillus badius and Bacillus lentus. Microbiological Research 162: 378-383, 2007. doi: 10.1016/j.micres.2006.01.008.

Jutur, P.P., and A.N. Asha. Microarrays and their applications - an versatile tool in understanding gene expression profiling. Bioinformatics Trends 1: 69-80, 2007.

Sumithra, K., Jutur, P.P., Dalton, B.C., and A.R. Reddy.  Salinity-induced changes in two cultivars of Vigna radiata:  responses of antioxidative and proline metabolism. Plant Growth Regulation 50: 11-22, 2006. doi: 10.1007/s10725-006-9121-7.

Desingh, R., Jutur, P.P., and A.R. Reddy. Salinity stress-induced changes in photosynthesis and antioxidative systems in three Casuarina species. Journal of Plant Biology 33: 155-161, 2006.

Reddy, A.R., Chaitanya, K.V., Jutur, P.P., and A. Gnanam.  Photosynthesis   and oxidative stress   responses   to   water   deficit   in   five   different   mulberry (Morus alba.  L)  cultivars. Physiology and Molecular Biology of Plants 11: 291-298, 2005.

Jutur, P.P., and A. R. Reddy.  BpaI and BpnI:  Type II restriction endonucleases from Bacillus pasteurii and Bacillus pantothenticus. Biotechnology Letters 26: 929-932, 2004. doi: 10.1023/ b:bile.0000025905.14101.39.

Jutur, P.P., Hoti, S.L., and A.R. Reddy. Bsu2413I and Bfi2411I, two new thermophilic type II restriction endonucleases from Bacillus subtilis and Bacillus firmus:  Isolation and   partial purification. Molecular Biology Reports 31:139-142, 2004. doi: 10.1023/b:mole.0000031503. 19851.3b.

Swarnalatha, M., Jutur, P.P., Amouda, V., Mathur, P.P., and A.R. Reddy. Prediction of transcriptional regulation by Dlx and Msx homeodomain proteins. Online Journal of Bioinformatics 5: 132-145, 2004.

Reddy, A.R., Chaitanya, K.V., and P.P. Jutur. Photosynthesis and drought adaptive characteristics in eight open pollinated families of Eucalyptus camaldulensis Dehn and Eucalyptus tereticornis Sm. In Tree Improvement and Biotechnology. edited by P. Shanmugavel and S. Ignachimuthu, Pointer publications, India, pp. 130-140, 2004.

Reddy, A.R., Chaitanya, K.V., Jutur, P.P., and K. Sumithra. Differential anti oxidative responses to water stress among five Mulberry (Morus alba L.) cultivars. Environmental and Experimental Botany 52: 33-42, 2004. doi: 10.1016/j.envexpbot.2004.01.002.

Sundar, D., Chaitanya, K.V., Jutur, P.P., and A.R. Reddy. Low temperature-induced changes in antioxidant metabolism in rubber-producing shrub, guayule (Parthenium argentatum    Gray). Plant Growth Regulation 44:    175-181, 2004. doi: 10.1007/s10725-004-4030-0.

Chaitanya, K.V., Jutur, P.P., Sundar, D., and A.R. Reddy. Water stress effects on photosynthesis in different mulberry cultivars. Plant Growth Regulation 40: 75-80, 2003. doi: 10.1023/ a:10230 64328384.

Jutur, P.P., and A.R. Reddy. Bioinformatics: an overview of its molecular tools in a user’s perspective. Bioinformatics India 1: 13-22, 2003.

Jutur, P.P., Chaitanya, K.V., and A.R. Reddy.   Proteomics:   an   overview   in developmental biology. Bioinformatics India 1: 65-73, 2003.

Chaitanya, K.V., Jutur, P.P., Masilamani, S., and A.R. Reddy. Biomass yields in relation to photosynthesis in four different cultivars of mulberry. Indian Journal of Plant Physiology 8: 158-163, 2003.

Jutur, P.P., and A.R. Reddy. A novel restriction endonuclease Bsu121I from Bacillus subtilis. Journal of Mycopathological Research 41: 247-250, 2003.

Jutur, P.P., and A.R. Reddy.  Isolation and partial purification of novel restriction endonuclease Bsu121I, from Bacillus subtilisMolecular Biology Reports 29: 383-385, 2002. doi: 10.1023/a:1021260803765.

Chaitanya, K.V., Masilamani, S., Jutur, P.P., and A.R. Reddy. Variation in photosynthetic rates and biomass productivity among four Mulberry cultivars. Photosynthetica 40: 305-308, 2002. doi: 10.1023/a: 1021318412861.

ICGEB New Delhi

ICGEB Campus
Aruna Asaf Ali Marg
110 067 New Delhi
INDIA
Tel: +91-11-26741358/1007
Fax: +91-11-26742316
icgebicgeb.res.in

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