Research Groups

Cellular Immunology

Research Interests and Description

Group Leader: Federica Benvenuti, PhD

Group Members

Research Interests

Suppression of immune responses in cancer and excessive activation of innate pathways in autoimmunity.

Description of Research

The lab has a major interest in the mechanisms that regulate priming of T cell responses by dendritic cells (DCs), under normal and pathological conditions. By combining immune phenotyping and cell-sorting of defined immune cell subsets to functional analysis and gene expression profiling we aim to identify the network of cellular and molecular interactions that leads to loss of DCs activity in lung cancer.
A second important lab’s objective is to decipher the causes of excessive type-I interferon responses in autoimmune diseases, with a special focus on the actin-related primary immune deficiency Wiskott-Aldrich syndrome. Here we apply a cell biology approach to understand the role of cytoskeletal proteins in initiation and termination of signals emanating from toll-like receptors in response to endogenous ligands.

Recent Publications

Cervantes-Luevano, K.E., Caronni, N., Castiello, M.C., Fontana, E., Piperno, G., Naseem, A., Uva, P., Bosticardo, M., Marcovecchio, G.E., Notarangelo, L.D., Cicalese, M.P., Aiuti, A., Villa, A., Benvenuti, F. 2018. Neutrophils drive type-I interferon production and autoantibodiesin Wiskott-Aldrich syndrome. J Allergy Clin Immunol pii:S0091-6749(18)30207-0. doi: 10.1016/j.jaci.2017.11.063. [Epub ahead of print] PubMed link

Caronni, N., Simoncello, F., Stafetta, F., Guarnaccia, C., Ruiz-Moreno, J.S., Opitz, B., Galli, T., Proux-Gillardeaux, V., Benvenuti, F. 2017. Downregulation of membrane trafficking proteins and lactate conditioning determine loss of dendritic cell function in lung cancer. Cancer Res. 2018 Jan 23. pii: canres.1307.2017. doi:
10.1158/0008-5472.CAN-17-1307. [Epub ahead of print] PubMed link

Campaner, E., Rustighi, A., Zannini, A., Cristiani, A., Piazza, S., Ciani, Y., Kalid, O., Golan, G., Baloglu, E., Shacham, S., Valsasina, B., Cucchi, U., Pippione, A.C., Lolli, M.L., Giabbai, B., Storici, P., Carloni, P., Rossetti, G., Benvenuti, F., Bello, E., D'Incalci, M., Cappuzzello, E., Rosato, A., Del Sal, G. 2017. A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action. Nat Commun 9, 15772 PubMed link

Castiello, M.C., Pala, F., Sereni, L., Draghici, E., Inverso, D., Sauer, A.V., Schena, F., Fontana, E., Radaelli, E., Uva, P., Cervantes-Luevano, K.E., Benvenuti, F., Poliani, P.L., Iannacone, M., Traggiai, E., Villa, A., Bosticardo, M. 2017. In Vivo Chronic Stimulation Unveils Autoreactive Potential of Wiskott-Aldrich Syndrome Protein-Deficient B Cells. Front Immunol 2, 490 PubMed link

Benvenuti, F. 2016. The Dendritic Cell Synapse: A Life Dedicated to T Cell Activation. Frontiers in immunology 7, 70 PubMed link

Chiaruttini, G., Piperno, G.M., Jouve, M., De Nardi, F., Larghi, P., Peden, A.A., Baj, G., Müller, S., Valitutti, S., Galli, T., Benvenuti, F. 2016. The SNARE VAMP7 regulates exocytic trafficking of Interleukin-12 in dendritic cells. Cell Rep 14, 2624-2636 PubMed link

Cod. Fisc. 90031700322 tl_files/trieste pics/5permille .png

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